Gamze Karaca
Associate Scientist III


Gamze received her M.Sc. degree from the University Delaware, Newark at the Department of Animal Science. There she has studied the molecular mechanism of how the Herpes Virus of Turkey (HVT) vaccine elicits a protective effect against Marek’s Disease Virus (MDV) infection in chickens. After receiving her degree, Gamze began working for the University of North Carolina at Chapel Hill in Dr. Charles M. Perou’s laboratory, gaining experience in molecular classification of breast cancer subtypes based on their gene expressions. Following breast cancer research, Gamze joined Dr. Anna M. Diehl’s laboratory in the Duke University and worked for 6 years in her research group, during which she studied the molecular mechanisms of acute and chronic liver diseases, such as non-alcoholic fatty liver diseases (NAFLD) and alcoholic steatohepatitis (ASH), using chemical and diet induced liver fibrosis animal models.
In September 2014, Gamze joined the Dr. Duffield as an Associate Scientist.

My interest outside the lab includes gardening and playing basketball with my son and daughter.


EDUCATION
2004 University of Delaware, Newark, DE M.Sc. in Animal Science
1993 Ankara University, Ankara, Turkey B.Sc. in Animal Science


SELECTED PUBLICATIONS
1. Karaca, G., M. Swiderska-Syn, G. Xie, W. K. Syn, L. Kruger, M. V. Machado, K. Garman, S. S. Choi, G. A. Michelotti, L. C. Burkly, B. Ochoa and A. M. Diehl (2014). "TWEAK/Fn14 signaling is required for liver regeneration after partial hepatectomy in mice." PLoS One 9(1): e83987.

2. Chan, I. S., C. D. Guy, M. V. Machado, A. Wank, V. Kadiyala, G. Michelotti, S. Choi, M. Swiderska-Syn, G. Karaca, T. A. Pereira, M. T. Yip-Schneider, C. Max Schmidt and A. M. Diehl (2014). "Alcohol activates the hedgehog pathway and induces related procarcinogenic processes in the alcohol-preferring rat model of hepatocarcinogenesis." Alcohol Clin Exp Res 38(3): 787-800.

3. Michelotti, G. A., G. Xie, M. Swiderska, S. S. Choi, G. Karaca, L. Kruger, R. Premont, L. Yang, W. K. Syn, D. Metzger and A. M. Diehl (2013). "Smoothened is a master regulator of adult liver repair." J Clin Invest 123(6): 2380-2394.

4. Swiderska-Syn, M., W. K. Syn, G. Xie, L. Kruger, M. V. Machado, G. Karaca, G. A. Michelotti, S. S. Choi, R. T. Premont and A. M. Diehl (2013). "Myofibroblastic cells function as progenitors to regenerate murine livers after partial hepatectomy." Gut.

5. Xie, G., S. S. Choi, W. K. Syn, G. A. Michelotti, M. Swiderska, G. Karaca, I. S. Chan, Y. Chen and A. M. Diehl (2013). "Hedgehog signalling regulates liver sinusoidal endothelial cell capillarisation." Gut 62(2): 299-309.

6. Xie, G., G. Karaca, M. Swiderska-Syn, G. A. Michelotti, L. Kruger, Y. Chen, R. T. Premont, S. S. Choi and A. M. Diehl (2013). "Cross-talk between Notch and Hedgehog regulates hepatic stellate cell fate in mice." Hepatology 58(5): 1801-1813.

7. Chan, I. S., C. D. Guy, Y. Chen, J. Lu, M. Swiderska-Syn, G. A. Michelotti, G. Karaca, G. Xie, L. Kruger, W. K. Syn, B. R. Anderson, T. A. Pereira, S. S. Choi, A. S. Baldwin and A. M. Diehl (2012). "Paracrine Hedgehog signaling drives metabolic changes in hepatocellular carcinoma." Cancer Res 72(24): 6344-6350.

8. Chen, Y., S. S. Choi, G. A. Michelotti, I. S. Chan, M. Swiderska-Syn, G. F. Karaca, G. Xie, C. A. Moylan, F. Garibaldi, R. Premont, H. B. Suliman, C. A. Piantadosi and A. M. Diehl (2012). "Hedgehog controls hepatic stellate cell fate by regulating metabolism." Gastroenterology 143(5): 1319-1329 e1311-1311.

9. Romac, J. M., R. A. Shahid, S. S. Choi, G. F. Karaca, C. B. Westphalen, T. C. Wang and R. A. Liddle (2012). "Pancreatic secretory trypsin inhibitor I reduces the severity of chronic pancreatitis in mice overexpressing interleukin-1beta in the pancreas." Am J Physiol Gastrointest Liver Physiol 302(5): G535-541.

10. Syn, W. K., K. M. Agboola, M. Swiderska, G. A. Michelotti, E. Liaskou, H. Pang, G. Xie, G. Philips, I. S. Chan, G. F. Karaca, A. Pereira Tde, Y. Chen, Z. Mi, P. C. Kuo, S. S. Choi, C. D. Guy, M. F. Abdelmalek and A. M. Diehl (2012). "NKT-associated hedgehog and osteopontin drive fibrogenesis in non-alcoholic fatty liver disease." Gut 61(9): 1323-1329.

11. Philips, G. M., I. S. Chan, M. Swiderska, V. T. Schroder, C. Guy, G. F. Karaca, C. Moylan, T. Venkatraman, S. Feuerlein, W. K. Syn, Y. Jung, R. P. Witek, S. Choi, G. A. Michelotti, F. Rangwala, E. Merkle, C. Lascola and A. M. Diehl (2011). "Hedgehog signaling antagonist promotes regression of both liver fibrosis and hepatocellular carcinoma in a murine model of primary liver cancer." PLoS One 6(9): e23943. 12. Syn, W. K., S. S. Choi, E. Liaskou, G. F. Karaca, K. M. Agboola, Y. H. Oo, Z. Mi, T. A. Pereira, M. Zdanowicz, P. Malladi, Y. Chen, C. Moylan, Y. Jung, S. D. Bhattacharya, V. Teaberry, A. Omenetti, M. F. Abdelmalek, C. D. Guy, D. H. Adams, P. C. Kuo, G. A. Michelotti, P. F. Whitington and A. M. Diehl (2011). "Osteopontin is induced by hedgehog pathway activation and promotes fibrosis progression in nonalcoholic steatohepatitis." Hepatology 53(1): 106-115.

13. Choi, S. S., W. K. Syn, G. F. Karaca, A. Omenetti, C. A. Moylan, R. P. Witek, K. M. Agboola, Y. Jung, G. A. Michelotti and A. M. Diehl (2010). "Leptin promotes the myofibroblastic phenotype in hepatic stellate cells by activating the hedgehog pathway." J Biol Chem 285(47): 36551-36560.

14. Choi, S. S., R. P. Witek, L. Yang, A. Omenetti, W. K. Syn, C. A. Moylan, Y. Jung, G. F. Karaca, V. S. Teaberry, T. A. Pereira, J. Wang, X. R. Ren and A. M. Diehl (2010). "Activation of Rac1 promotes hedgehog-mediated acquisition of the myofibroblastic phenotype in rat and human hepatic stellate cells." Hepatology 52(1): 278-290.

15. Ochoa, B., W. K. Syn, I. Delgado, G. F. Karaca, Y. Jung, J. Wang, A. M. Zubiaga, O. Fresnedo, A. Omenetti, M. Zdanowicz, S. S. Choi and A. M. Diehl (2010). "Hedgehog signaling is critical for normal liver regeneration after partial hepatectomy in mice." Hepatology 51(5): 1712-1723.

16. Pereira Tde, A., R. P. Witek, W. K. Syn, S. S. Choi, S. Bradrick, G. F. Karaca, K. M. Agboola, Y. Jung, A. Omenetti, C. A. Moylan, L. Yang, M. E. Fernandez-Zapico, R. Jhaveri, V. H. Shah, F. E. Pereira and A. M. Diehl (2010). "Viral factors induce Hedgehog pathway activation in humans with viral hepatitis, cirrhosis, and hepatocellular carcinoma." Lab Invest 90(12): 1690-1703.

17. Syn, W. K., Y. H. Oo, T. A. Pereira, G. F. Karaca, Y. Jung, A. Omenetti, R. P. Witek, S. S. Choi, C. D. Guy, C. M. Fearing, V. Teaberry, F. E. Pereira, D. H. Adams and A. M. Diehl (2010). "Accumulation of natural killer T cells in progressive nonalcoholic fatty liver disease." Hepatology 51(6): 1998-2007.

18. Syn, W. K., Y. Jung, A. Omenetti, M. Abdelmalek, C. D. Guy, L. Yang, J. Wang, R. P. Witek, C. M. Fearing, T. A. Pereira, V. Teaberry, S. S. Choi, J. Conde-Vancells, G. F. Karaca and A. M. Diehl (2009). "Hedgehog-mediated epithelial-to-mesenchymal transition and fibrogenic repair in nonalcoholic fatty liver disease." Gastroenterology 137(4): 1478-1488 e1478.