Giovanni Ligresti, PhD


Education and Professional Training
University of Udine, PhD Biotechnology, 2008
University of Catania and East Carolina University, Post Doc, 2008


Areas of Interest
Molecular Discovery
Vascular Regeneration


Original Articles
Kelly, Edward J., Zhican Wang, Jenna L. Voellinger, Cathy K. Yeung, Danny D. Shen, Kenneth E. Thummel, Ying Zheng, Giovanni Ligresti , David L. Eaton, Kimberly A. Muczynski, Jeremy S. Duffield, Thomas Neumann, Anna Tourovskaia, Mark Fauver, Greg Kramer, Elizabeth Asp, and Jonathan Himmelfarb. "Innovations in Preclinical Biology: Ex Vivo Engineering of a Human Kidney Tissue Microperfusion System." Stem Cell Research & Therapy 4.Suppl 1 (2013): S17.

Aplin, Alfred C., Giovanni Ligresti, Eric Fogel, Penolope Zorzi, Kelly Smith, and Roberto F. Nicosia. "Regulation of Angiogenesis, Mural Cell Recruitment and Adventitial Macrophage Behavior by Toll-like Receptors." Angiogenesis 17.1 (2014): 147-61.

Mccubrey, James A., Linda S. Steelman, William H. Chappell, Lin Sun, Nicole M. Davis, Stephen L. Abrams, Richard A. Franklin, Lucio Cocco, Camilla Evangelisti, Francesca Chiarini, Alberto M. Martelli, Massimo Libra, Saverio Candido, Giovanni Ligresti , Grazia Malaponte, Maria C. Mazzarino, Paolo Fagone, Marco Donia, Ferdinando Nicoletti, Jerry Polesel, Renato Talamini, Jörg Bäsecke, Sanja Mijatovic, Danijela Maksimovic-Ivanic, Michele Milella, Agostino Tafuri, Joanna Dulińska-Litewka, Piotr Laidler, Antonio B. Antonio, Lyudmyla Drobot, Kazuo Umezawa, Giuseppe Montalto, Melchiorre Cervello, and Zoya N. Demidenko. "Targeting Signal Transduction Pathways to Eliminate Chemotherapeutic Drug Resistance and Cancer Stem Cells." Advances in Enzyme Regulation 50.1 (2010): 285-307.

Campanholle, G., G. Ligresti , S. A. Gharib, and J. S. Duffield. "Cellular Mechanisms of Tissue Fibrosis. 3. Novel Mechanisms of Kidney Fibrosis." AJP: Cell Physiology 304.7 (2013): C591-603.

Ligresti, Giovanni , Alfred C. Aplin, Bruce E. Dunn, Ann Morishita, and Roberto F. Nicosia. "The Acute Phase Reactant Orosomucoid-1 Is a Bimodal Regulator of Angiogenesis with Time- and Context-Dependent Inhibitory and Stimulatory Properties." Ed. Jeremy Stuart Duffield. PLoS ONE 7.8 (2012): E41387.

Mccubrey, James A., Linda S. Steelman, Stephen L. Abrams, Negin Misaghian, William H. Chappell, Ferdinando Nicoletti, Jorg Basecke, Massimo Libra, Giovanni Ligresti , Francac Stivala, Danijela Maksimovic-Ivanic, Sanja Mijatovic, Giuseppeo Montalto, Melchiorre Cervello, Piotr Laidler, Antonio Bonati, Camilla Evangelisti, Lucio Cocco, and Alberto M. Martelli. "Targeting the Cancer Initiating Cell: The Ultimate Target for Cancer Therapy." Current Pharmaceutical Design 18.13 (2012): 1784-795.

Hafsi, Sameh, Franca Maria Pezzino, Saverio Candido, Giovanni Ligresti , Demetrios A. Spandidos, Zohra Soua, James A. McCubrey, Salvatore Travali, and Massimo Libra. "Gene Alterations in the PI3K/PTEN/AKT Pathway as a Mechanism of Drug-resistance (Review)." International Journal of Oncology 40.3 (2011): 639-44.

Nicosia, Roberto F., Penelope Zorzi, Giovanni Ligresti , Ann Morishita, and Alfred C. Aplin. "Paracrine Regulation of Angiogenesis by Different Cell Types in the Aorta Ring Model." The International Journal of Developmental Biology 55.4-5 (2011): 447-53.

Ligresti, G. , A. C. Aplin, P. Zorzi, A. Morishita, and R. F. Nicosia. "Macrophage-Derived Tumor Necrosis Factor- Is an Early Component of the Molecular Cascade Leading to Angiogenesis in Response to Aortic Injury." Arteriosclerosis, Thrombosis, and Vascular Biology 31.5 (2011): 1151-159.

Mongiat, Maurizio, Stefano Marastoni, Giovanni Ligresti , Erica Lorenzon, Monica Schiappacassi, Roberto Perris, Sergio Frustaci, and Alfonso Colombatti. "The Extracellular Matrix Glycoprotein Elastin Microfibril Interface Located Protein 2: A Dual Role in the Tumor Microenvironment." Neoplasia 12.4 (2010): 294-304.

Castellano, Giancarlo, Elena Torrisi, Giovanni Ligresti , Ferdinando Nicoletti, Grazia Malaponte, Salvatore Travali, James A. Mccubrey, Silvana Canevari, and Massimo Libra. "Yin Yang 1 Overexpression in Diffuse Large B-cell Lymphoma Is Associated with B-cell Transformation and Tumor Progression." Cell Cycle 9.3 (2010): 557-63.

Castellano, Giancarlo, Elena Torrisi, Giovanni Ligresti , Grazia Malaponte, Loredana Militello, Alessia E. Russo, James A. Mccubrey, Silvana Canevari, and Massimo Libra. "The Involvement of the Transcription Factor Yin Yang 1 in Cancer Development and Progression." Cell Cycle 8.9 (2009): 1367-372.

Ligresti, Giovanni , Loredana Militello, Linda S. Steelman, Andrea Cavallaro, Francesco Basile, Ferdinando Nicoletti, Franca Stivala, James A. Mccubrey, and Massimo Libra. "PIK3CA Mutations in Human Solid Tumors: Role in Sensitivity to Various Therapeutic Approaches." Cell Cycle 8.9 (2009): 1352-358.

Ligresti, Giovanni , Massimo Libra, Loredana Militello, Silvia Clementi, Marco Donia, Rosa Imbesi, Grazia Malaponte, Alessandro Cappellani, and James A. Cappellani. "Breast Cancer: Molecular Basis and Therapeutic Strategies (Review)." Molecular Medicine Reports 1.4 (2008): 451-58.

Mccubrey, James A., Melissa L. Sokolosky, Brian D. Lehmann, Jackson R. Taylor, Patrick M. Navolanic, William H. Chappell, Stephen L. Abrams, Kristin M. Stadelman, Ellis W.t. Wong, Negin Misaghian, Stefan Horn, Jörg Bäsecke, Massimo Libra, Franca Stivala, Giovanni Ligresti , Agostino Tafuri, Michele Milella, Marek Zarzycki, Andrzej Dzugaj, Francesca Chiarini, Camilla Evangelisti, Alberto M. Martelli, David M. Terrian, Richard A. Franklin, and Linda S. Steelman. "Alteration of Akt Activity Increases Chemotherapeutic Drug and Hormonal Resistance in Breast Cancer Yet Confers an Achilles Heel by Sensitization to Targeted Therapy." Advances in Enzyme Regulation 48.1 (2008): 113-35.

Doliana, Roberto, Veljko Veljkovic, Jelena Prljic, Nevena Veljkovic, Elisa De Lorenzo, Maurizio Mongiat, Giovanni Ligresti , Stefano Marastoni, and Alfonso Colombatti. "EMILINs Interact with Anthrax Protective Antigen and Inhibit Toxin Action in Vitro." Matrix Biology 27.2 (2008): 96-106.

Mongiat, M., G. Ligresti , S. Marastoni, E. Lorenzon, R. Doliana, and A. Colombatti. "Regulation of the Extrinsic Apoptotic Pathway by the Extracellular Matrix Glycoprotein EMILIN2." Molecular and Cellular Biology 27.20 (2007): 7176-187.

Libra, Massimo, Grazia Malaponte, Valentina Bevelacqua, Roberta Siciliano, Paola Castrogiovanni, Alberto Fulvi, Giuseppe Micali, Giovanni Ligresti , Maria C. Mazzarino, Franca Stivala, Salvatore Travali, and James A. McCubrey. "Absence of BRAF Gene Mutation in Non-Melanoma Skin Tumors." Cell Cycle 5.9 (2006): 968-70.