Lan Dang, PhD
Postdoctoral Scientist


I joined the Duffield Lab at Biogen in 2015 to investigate the function of the endothelium during kidney injury. My research consists of interrelated projects that are focused on molecular pathways, as well as other environmental stimuli (such as extracellular matrix architecture and vascular mural cell interactions) that regulate the regenerative and angiogenic potential of the microvascular network following kidney injury. I work in close collaboration with the Human Physiological Systems Core, headed by Graham Marsh and Angela Huang, to utilize tissue engineering approaches for my studies.

My undergraduate studies in molecular genetics at the University of Toronto fostered my interest in gene regulation networks and their interactions with signaling pathways during early embryonic development. As a result, I pursued my doctoral studies under the supervision of Dr. Vincent Tropepe at the University of Toronto where I investigated the transcriptional mechanisms that control the differentiation of mouse embryonic stem cells into cells of the neural lineage. In 2010, I joined the Functional Tissue Engineering Lab of Dr. Milica Radisic and was able to garner invaluable experience in tissue engineering and regenerative medicine. In Dr. Radisic’s lab, I investigated a biomaterials-based approach to prevent apoptosis in human iPS cells. In 2012, I joined Dr. Jason Fish’s lab at the Toronto General Research Institute to investigate the molecular mechanisms that regulate the formation and function of the vasculature. In collaboration with Dr. Benoit Bruneau’s lab at the Gladstone Institute, we identified novel transcriptional pathways that regulate the specification of blood vessels into arteries and veins. Furthermore, I was able to expand on these studies to identify transcriptional mechanisms induced in tip cells during sprouting angiogenesis.


Publications

Njock, M.S., Cheng, H.S., Dang, L.T., Nazari-Jahantigh, M., Boudreau, E., Gauthier-Fisher, A., Librach, C.L., Cybulsky, M.I., Schober, A., Fish, J.E. (2014) Endothelial cells reprogram inflammatory responses through secretion of microvesicles containing anti-inflammatory microRNAs. Blood 125(20): 3202-3212.

Cheng, H.S., Njock, M.S., Khyzha, N., Dang, L.T.H., Fish, J.E. (2014) Noncoding RNAs regulate NF-kB signaling to modulate blood vessel inflammation. Frontiers in Genetics 5:422.

Delgado-Olguin, P., Dang, L.T.H., He, D., Thomas, S., Chi, L., Sukonnik, T., Dobenecker, M.W., Fish, J.E., and Bruneau, B.G. (2014) Ezh2-mediated repression of a transcriptional pathway upstream of Mmp9 maintains integrity of the developing vasculature. Development 141:4610-4617.

Dang, L.T.H., Feric, N., Laschinger, C., Chang, W.Y., Zhang, B., Wood, G., Stanford, W.L., and Radisic, M. (2014) Inhibition of apoptosis in human induced pluripotent stem cells during expansion in a defined culture using angiopoietin-1 derived peptide QHREDGS. Biomaterials 35(27): 7786-7799.

Wythe, J., Dang, L.T.H., Devine, P., Boudreau, E., Artap, S.T., Schachterle, W., Stainier, D.Y., Oettgen, P., Black, B.L., Bruneau, B.G., Fish, J.E. (2013) ETS factors regulate the Vegf dependent, arterial-specific expression of Dll4. Developmental Cell 26: 45-58.

Dang, L.T.H., Lawson, N., and Fish, J.E. (2013) MicroRNA control of Vegf signalling output during vascular development. Arteriosclerosis, Thrombosis, and Vascular Biology 33(2):193-200.

Dang, L.T.H., Wong, L. and Tropepe, V. (2012) Zfhx1b induces a definitive neural stem cell fate in mouse ES cells. Stem Cells and Development 21(15): 2838-2851.

Dang, L.T.H. and Tropepe, V. (2010) FGF dependent regulation of Zfhx1b gene expression promotes the formation of definitive neural stem cells in the mouse anterior neurectoderm. Neural Development 5:13. PMID: 20459606.

Dang, L. and Tropepe, V. (2006) Neural induction and neural stem cell development. Regenerative Medicine 1(5): 635-652.