Naoki Nakagawa, MD, PhD


I got my MD from Jichi Medical University in 1997 and my PhD from Asahikawa Medical University, Japan in 2012. In the past, I had focused my time on clinical treatment of patients with various kidney diseases including patients who required blood purification therapy in some Japanese hospitals. In my PhD course, I investigated the roles of prostaglandin E2 (PGE2) via its EP4 receptor in the development of renal fibrosis in mice. In August 2012, I joined Dr. Duffield’s laboratory. The focus of my projects is the role of regulatory macrophages and pericytes in kidney disease. In my spare time, I enjoy spending time with my family, skiing, and watching sports, especially baseball.

Selected Publications:

1. The intrinsic prostaglandin E2-EP4 system of the renal tubular epithelium limits the development of tubulointerstitial fibrosis in mice. Nakagawa N, Yuhki K, Kawabe J, Fujino T, Takahata O, Kabara M, Abe K, Kojima F, Kashiwagi H, Hasebe N, Kikuchi K, Sugimoto Y, Narumiya S, Ushikubi F. Kidney Int. 2012 Jul;82(2):158-71.

2. Prostaglandin I2 promotes recruitment of endothelial progenitor cells and limits vascular remodeling. Kawabe J, Yuhki K, Okada M, Kanno T, Yamauchi A, Tashiro N, Sasaki T, Okumura S, Nakagawa N, Aburakawa Y, Takehara N, Fujino T, Hasebe N, Narumiya S, Ushikubi F. Arterioscler Thromb Vasc Biol. 2010 Mar;30(3):464-70.

3. An oral adsorbent, AST-120, suppresses oxidative stress in uremic rats. Nakagawa N, Hasebe N, Sumitomo K, Fujino T, Fukuzawa J, Hirayama T, Kikuchi K. Am J Nephrol. 2006;26(5):455-61.

4. Decreased susceptibility to renovascular hypertension in mice lacking the prostaglandin I2 receptor IP. Fujino T, Nakagawa N, Yuhki K, Hara A, Yamada T, Takayama K, Kuriyama S, Hosoki Y, Takahata O, Taniguchi T, Fukuzawa J, Hasebe N, Kikuchi K, Narumiya S, Ushikubi F. J Clin Invest. 2004 Sep;114(6):805-12.