Shuyu Ren, PhD


Current areas of research


Education and Professional Training

Johann Wolfgang Goethe University Frankfurt, Ph.D Molecular pharmacology, 2001.

Johann Wolfgang Goethe University Frankfurt, Postdoc, 2005/2006

Institute of Pharmacology, University of Bern, postdoc, 2006/2009


Original Articles

1. Transforming growth factor-beta2 upregulates sphingosine kinase-1 activity, which in turn attenuates the fibrotic response to TGF-beta2 by impeding CTGF expression.

Ren S, Babelova A, Moreth K, Xin C, Eberhardt W, Doller A, Pavenstädt H, Schaefer L, Pfeilschifter J, Huwiler A.

Kidney Int. 2009 Oct;76(8):857-67. Epub 2009 Aug 5.


2. Sphingosine kinase 1 and 2 regulate the capacity of mesangial cells to resist apoptotic stimuli in an opposing manner.

Hofmann LP, Ren S, Schwalm S, Pfeilschifter J, Huwiler A.

Biol Chem. 2008 Nov;389(11):1399-407.


3. Sphingosylphosphorylcholine acts in an anti-inflammatory manner in renal mesangial cells by reducing interleukin-1beta-induced prostaglandin E2 formation.

Xin C, Ren S.* (Authors contributed equally), Eberhardt W, Pfeilschifter J, Huwiler A.

J Lipid Res. 2007 Sep;48(9):1985-96. Epub 2007 Jun 25.


4. FTY720 suppresses interleukin-1beta-induced secretory phospholipase A2 expression in renal mesangial cells by a transcriptional mechanism.

Xin C, Ren S.* (Authors contributed equally), Eberhardt W, Pfeilschifter J, Huwiler A.

Br J Pharmacol. 2007 Apr;150(7):943-50. Epub 2007 Feb 26.


5. Histamine increases sphingosine kinase-1 expression and activity in the human arterial endothelial cell line EA.hy 926 by a PKC-alpha-dependent mechanism.

Huwiler A, Döll F, Ren S, Klawitter S, Greening A, Römer I, Bubnova S, Reinsberg L, Pfeilschifter J.

Biochim Biophys Acta. 2006 Mar;1761(3):367-76. Epub 2006 Mar 10.


6. The immunomodulator FTY720 and its phosphorylated derivative activate the Smad signalling cascade and upregulate connective tissue growth factor and collagen type IV expression in renal mesangial cells.

Xin C, Ren S.* (Authors contributed equally), Eberhardt W, Pfeilschifter J, Huwiler A.

Br J Pharmacol. 2006 Jan;147(2):164-74.


7. PPARalpha activation upregulates nephrin expression in human embryonic kidney epithelial cells and podocytes by a dual mechanism.

Ren S, Xin C, Beck KF, Saleem MA, Mathieson P, Pavenstädt H, Pfeilschifter J, Huwiler A.

Biochem Biophys Res Commun. 2005 Dec 30;338(4):1818-24. Epub 2005 Nov 2.


8. Heterologous desensitization of the sphingosine-1-phosphate receptors by purinoceptor activation in renal mesangial cells.

Xin C, Ren S, Pfeilschifter J, Huwiler A.

Br J Pharmacol. 2004 Nov;143(5):581-9. Epub 2004 Oct 4.


9. Nephrin expression is increased in anti-Thy1.1-induced glomerulonephritis in rats.

Schaefer L, Ren S, Schaefer RM, Mihalik D, Babelova A, Huwiler A, Pfeilschifter J.

Biochem Biophys Res Commun. 2004 Nov 5;324(1):247-54.


10. Sphingosine 1-phosphate cross-activates the Smad signaling cascade and mimics transforming growth factor-beta-induced cell responses.

Xin C, Ren S, Kleuser B, Shabahang S, Eberhardt W, Radeke H, Schäfer-Korting M, Pfeilschifter J, Huwiler A.

J Biol Chem. 2004 Aug 20;279(34):35255-62. Epub 2004 Jun 10.


11. Inflammatory cytokines upregulate nephrin expression in human embryonic kidney epithelial cells and podocytes.

Huwiler A, Ren S.* (Authors contributed equally), Holthöfer H, Pavenstädt H, Pfeilschifter J.

Biochem Biophys Res Commun. 2003 May 23;305(1):136-42.


12. Interleukin-1beta inhibits ATP-induced protein kinase B activation in renal mesangial cells by two different mechanisms: the involvement of nitric oxide and ceramide.

Rölz W, Xin C, Ren S, Pfeilschifter J, Huwiler A.

Br J Pharmacol. 2003 Feb;138(3):461-8.


13. Interleukin-1 inhibits angiotensin II-stimulated protein kinase B pathway in renal mesangial cells via the inducible nitric oxide synthase.

Rölz W, Xin C, Ren S, Pfeilschifter J, Huwiler A.

Eur J Pharmacol. 2002 May 10;442(3):195-203.


14. Extracellular ATP and UTP activate the protein kinase B/Akt cascade via the P2Y(2) purinoceptor in renal mesangial cells.

Huwiler A, Rölz W, Dorsch S, Ren S, Pfeilschifter J.

Br J Pharmacol. 2002 Jun;136(4):520-9.