Takahisa Kawakami, MD, PhD

I graduated from the University of Tokyo School of Medicine, Japan, in 2000. After I underwent clinical training in internal medicine and nephrology, I joined Dr. Masaomi Nangaku’s laboratory as a postgraduate student, and completed research in endoplasmic reticulum stress and autophagy in renal tubular cells. I received my PhD in 2008 and continued to do research as a postdoctoral fellow. Concurrently, I was also director of a dialysis clinic and dedicated to taking care of a hundred patients. In June 2011, I joined Dr. Duffield’s laboratory. My project themes are mononuclear phagocytic cells, autophagy, and pericytes in kidneys.


1. Indoxyl sulfate inhibits proliferation of human proximal tubular cells via endoplasmic reticulum stress. Kawakami T, Inagi R, Wada T, Tanaka T, Fujita T, Nangaku M. Am J Physiol Renal Physiol 2010 Sep;299(3):F568-76

2. Uremia induces abnormal oxygen consumption in tubules and aggravates chronic hypoxia of the kidney via oxidative stress. Palm F, Nangaku M, Fasching A, Tanaka T, Nordquist L, Hansell P, Kawakami T, Nishijima F, Fujita T. Am J Physiol Renal Physiol 2010 Aug;299(2):F380-6

3. Myeloperoxidase antineutrophil cytoplasmic antibody-associated vasculitis with diffuse tubulointerstitial nephritis. Son D, Kanda H, Yamaguchi A, Kawabata K, Kawakami T, Kubo K, Higashihara M, Shimizu J, Uozaki H, Kuramochi S, Misaki Y, Takeuchi F, Yamamoto K. J Nephrol 2009 May-Jun;22(3):417-20

4. Endoplasmic reticulum stress induces autophagy in renal proximal tubular cells. Kawakami T, Inagi R, Takano H, Sato S, Ingelfinger JR, Fujita T, Nangaku M. Nephrol Dial Transplant 2009 Sep;24(9):2665-72.

5. Preconditioning with endoplasmic reticulum stress ameliorates mesangioproliferative glomerulonephritis. Inagi R, Kumagai T, Nishi H, Kawakami T, Miyata T, Fujita T, Nangaku M. J Am Soc Nephrol 2008 May;19(5):915-22.