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Tissue-resident mesenchymal stromal cells: Implications for tissue-specific antifibrotic therapies.

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Tissue-resident mesenchymal stromal cells: Implications for tissue-specific antifibrotic therapies.

Sci Transl Med. 2018 Jan 31;10(426):

Authors: Lemos DR, Duffield JS

Abstract
Recent scientific findings support the notion that fibrosis is driven by tissue-specific cellular and molecular mechanisms. Analysis of seemingly equivalent mesenchymal stromal cell (MSC) populations residing in different organs revealed unique properties and lineage capabilities that vary from one anatomical location to another. We review recently characterized tissue-resident MSC populations with a prominent role in fibrosis and highlight therapeutically relevant molecular pathways regulating their activity in chronic disease.

PMID: 29386358 [PubMed - in process]